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Resveratrol is classified in a group of compounds called polyphenols. Micronutrients derived from plants; polyphenols are liked for their high antioxidant potential. For people who are unversed with the term “antioxidants,” these are the same components that help protect our body cells against free radical damage and toxins of all kinds. Such shielding is vital to maintain a health free from diseases and certain cancers. Though several food items carry an abundant source of antioxidants, nothing compares to a supplement. This is not to say that eating fruits and vegetables is inadequate. Instead, our editorial team believes that extra support provided by supplements can help fulfill one’s daily requirements.
Speaking of supplements, this is where things get a little tricky because we live in a society where new strategies are regularly introduced. Thus, among the thousands that exist, how does one go about choosing that one product? This is where our editorial team can be of assistance, as the research involved exhilarates us. On that note, let’s just say that we decided to take matters into our own hands and consequently landed on 20 resveratrol supplements that may support healthy antioxidants ingestion. Furthermore, any one of these could provide cells, the immune system, and our hearts a chance at a well-deserving break from overworking themselves. Taking everything into account, it’s time we introduce our top picks.
The Top 20 Resveratrol Supplements in 2021
Before summarizing each of the 20 picks, our editorial team wanted to give a sneak peek into how this process was simplified. Precisely, our team members sat down and investigated each company, strategies, selected ingredients, and doses, among several crucial factors. We realized the importance of setting some expectations, and the best way to do so is by developing a ranking system. The more boxes checked off, the better is how we perceive things. In addition, we looked for popularly sold products. This is somewhat unconventional but unveils a story of its own regarding the pros and cons of just sticking to popularity. Nevertheless, here are our picks in a randomized manner:
- Biotivia Transmax
- Claritox Pro
- Cymbiotika NMN
- Designs for Health Resveratrol Supreme
- Garden of Life Raw Resveratrol
- Life Extension Optimized Resveratrol
- MAAC10 Trans-Resveratrol
- Nuzena Resveratrol Rapid +
- Purely Beneficial Resveratrol 1450
- Reserveage Nutrition Resveratrol
- Revitaa Pro
- The Red Wine Diet
- Thorne Research ResveraCel
- Toniiq Elixr
- Toniiq Resveratrol
- Vivo Tonic
- Zenith Labs Longevity Activator
- Company: Biotivia
- Starting Price: $74
The bio-enhanced, Transmax is advertised to deliver 98% trans-resveratrol. Based in New York, Biotivia is the creator and insists that their solution provides essential antioxidants that help to neutralize free radicals, maintain healthy glucose levels, and may mimic the benefits of a calorie-restricted diet. Free from silica, stearates, fillers, artificial and animal ingredients, and preservatives, among others, taking two capsules daily may promote wellness in the long run.
Speaking of serving sizes, each one contains not only Trans-Resveratrol (Polygonum cuspidatum) (500mg) but also Piperine (5mg) and Polydatin (5mg). On the topic of the company, their official website is currently under construction, but we managed to find news pieces that depict their good and bad sides. It looks like earlier in the game, the team failed to comply with regulations on labeling and health claims, which they have since rectified .
Then, they had to make their case surrounding falsified test results by a third-party scientist, one that the team claims they do not associate with . In both cases, the company was under much scrutiny; however, they neither fell silent nor quit. They ensured that everything was corrected for, which says enough about the company.
- Company: N/A
- Starting Price: $69
67-year-old Jim Benson claims to have spent decades researching the best ways to support balance and prevent individuals from experiencing dizziness and related injuries. Interestingly, he developed Claritox Pro with locally sourced natural ingredients with maturity in mind. The outcome is a dietary supplement that offers:
- Zinc (11mg)
- Chromium (100mcg)
- Alpha Lipoic Acid (150mg)
- Green Tea (150mg)
- Berberine (100mg)
- Resveratrol from Polygonum cuspidatum (40mg)
- A 112mg-proprietary blend of Milk Thistle, Silymarin, Cayenne, Panax Ginseng, and Banaba Leaf Extract
Alas, our editorial team was unsuccessful in validating Jim Benson’s credentials as a researcher, and very little has been disclosed about the manufacturing company. In this case, the absence of transparency is a red flag in our books, which makes us wonder how this supplement even garnered presence in the first place.
- Company: Cymbiotika
- Starting Price: $77
NMN, short for nicotinamide mononucleotide, is a precursor of an essential molecule called nicotinamide adenine dinucleotide (NAD+). The Cymbiotika team believes that their decision to find ways to enhance NAD+ is strategic given that it contributes to “mitochondrial function, energy, metabolism, and maintenance of healthy gene expression.” So, by triggering NMN levels, NAD is boosted, especially in times of aging where quantities are depleted.
Speaking of Cymbiotika, the company reflects the coming together of scientists and doctors who emphasize introducing advanced delivery systems, ensuring the body’s ability to absorb nutrients, and sourcing the purest of ingredients. Additionally, the team vouches to formulate products free from chemicals, animal products, common allergens, binders, you name it. Getting back to the formula, in addition to NMN (400mg), each serving (i.e., two capsules) represents the combined effects of Apigenin 98% (200mg), Green Tea Extract (200mg), Trans-resveratrol 98% (100mg), and Green Coffee Bean (100mg).
- Company: Designs for Health
- Starting Price: $61
Resveratrol Supreme is a dietary supplement that aims to fuel the body with polyphenol resveratrol. Given that it helps to activate the SirT1 gene to promote healthy aging effects, this supplement was bound to have been introduced at some point. Resveratrol Supreme is said to help maintain aging processes and neurological health, and the cardiovascular system. Not one but two potent antioxidants have been integrated into this formula. Specifically, each serving (i.e., 1 capsule) contains Trans-resveratrol (from Polygonum cuspidatum) (200mg) and Quercetin (200mg).
A facet that drew us to Design for Health is that the team flourished into existence because they were “united by science.” Forget ambiguity, as this company firmly stands by science-based nutrition and natural medicine while finding ways to provide advanced education on each product offered. As collectively stated, “We will keep discovering […] connecting […] fearlessly advocating for the greater good […] Here, holistic thinking comes first. Functional medicine becomes conventional medicine.” For interested parties, it might be worth checking out their library of research and development!
- Company: Garden of Life
- Starting Price: $35
Raw Resveratrol by Garden of Life has been formulated to assist the body in the fight against oxidative stress and cells in the fight against free radical damage. Moreover, this formula is trusted to promote regularity, digestive comfort, and “healthy elimination.” As suggested in the brand’s name, Garden of Life is all about promoting the effect of natural foods on reversing or alleviating health implications. The team pledges to follow their fundamental principles every step of the way, which include rejoicing “the science of whole food, traceability, and clean is healthy.” Besides those described above, this company has been granted USDA Organic, Non-GMO Verified, and Certified Vegan certifications.
With everything in mind, the Raw Resveratrol formula is split among three blends. The first is called the Raw Resveratrol Blend (578mg), which combines Organic Cabernet Sauvignon Grapes and Fermented Japanese Knotweed. The second is called the Raw Organic Antioxidant Blend (25mg), encompassing Apple, Beet, Broccoli, Tomato, Strawberry, Tart Cherry, Blackberry, Green Bell Pepper, Brussels Sprout, Blueberry, Ginger, Garlic, Green Onion, Raspberry, Parsley, Cauliflower, Red Cabbage, Kale, Cucumber, Celery, and Asparagus.
Finally, we have the Raw Probiotic and Enzyme Blend (500 million CFU), which includes Lipase, Protease, Aspergillopepsin, Beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Xylanase, and Hemicellulase.
- Company: Juvenon
- Starting Price: $39.95
In the Juvenon team’s viewpoint, maintaining healthy organs starts by ensuring strong blood circulation. For the latter to hold, nitric oxide levels need boosting so that our arteries can open and permit blood to move freely. This free movement is what guarantees the delivery of nutrients and oxygen to our very cells. Everything regarding Juvenon’s strategy is what BloodFlow-7 reflects. Specifically, it can promote healing, prolong the effects of aging, and ensure sustained energy and stamina levels. Nitric oxide is delicate to the presence of oxidative stress, hence the need for antioxidants.
What initially drew us to Juvenon is their goal of adding “five years of health to millions of customers’ lives.” As we dove deeper into our search, we soon realized it was founded by the University of California professor of biochemistry and molecular biology, Dr. Bruce Ames. He also happens to have invented the bubble chamber and has over 500 publications. This signifies the role that scientific research is bound to have had on the BloodFlow-7 formula, not to forget independent lab testing for safety, purity, and quality!
Nevertheless, each BloodFlow-7 serving (i.e., three capsules) reflects a 1080mg-Nitric Oxide Precursor Blend (i.e., L-Citrulline, L-Arginine HCl, Setria), Beet Root Extract (100mg), a 50mg-S7 Blend of Green Coffee Bean Extract, Green Tea Leaf Extract, Turmeric Root Extract, Tart Cherry, Blueberry, Broccoli, and Kale, and Trans-Resveratrol (30mg).
- Company: Life Extension
- Starting Price: $33.75
Life Extension maintains that Optimized Resveratrol has been designed to preserve health and longevity with Japanese Knotweed-extract Resveratrol. In addition, its inclusion supposedly implies bettered vascular health, healthy insulin sensitivity and mitochondrial function, inflammatory response, and cardiovascular health. For a team known for being vocal about the nutrition that science can offer, Life Extension insists that everyone should become an expert of their respective bodies, which starts by understanding the “science of wellness.”
Just how a doctor’s assistance might differ from a nutritionist’s, this team believes that they can help in different ways to arrive at wellness. In particular, they promise to be there at “every step of the way with formulas that do what we say they do,” as well as providing free access to wellness specialists and the informative LE Magazine and stressing the importance of lab testing. That said, every capsule houses the likes of Trans-resveratrol from Japanese Knotweed (250mg), Quercetin (150mg), Grapefruit and Wild Blueberry Blend (85mg), and Fisetin (10mg).
- Company: GenicsCare
- Starting Price: $59
LiGenics is a metabolism-boosting formula that allegedly targets four pillars using a series of antioxidants. In turn, this is reckoned to guarantee successful weight loss. They include triggering adipogenesis (i.e., essential in limiting the risk of lipotoxicity), insulin balance (i.e., for healthy blood sugar levels), stable metabolic rate (i.e., for consistent digestion and weight loss), and hormone balance (i.e., a factor needed to upkeep the former three pillars).
As far as the ingredient list goes, it includes Zinc, Chromium, Alpha Lipoic Acid, Green Tea Leaf Extract, Berberine, Resveratrol, Milk Thistle, Cayenne Extract, Panax Ginseng, and Banaba. Unfortunately, we have not been provided with a supplement’s fact outlining each ingredient’s concentrations, nor is there any way to trace it back to the GenicsCare company. Once again, multiple red flags rose as we investigated this purportedly in-demand solution!
- Company: MAAC10
- Starting Price: $29.99
Among all the resveratrol supplements discussed so far, MAAC10’s Trans-Resveratrol is slightly different because it delivers 99% Pure Trans-resveratrol (500mg) instead of 98%. Moreover, the particles are micron-sized, which will heighten absorption and include BioPerine (10mg). The MAAC10 strategy also involves tackling NAD content, as this decreases in production with age. The advertisement suggests the inclusion of NMN, but the supplement’s fact suggests otherwise. This discrepancy needs to be verified with the MAAC10 team before investing.
Nevertheless, MAAC10’s approach has been well-received, as Amazon customer reviews average out to a total of 4.6 stars out of 5. Complaints were mainly surrounding its capsule size and taste, with some experiencing little to no effects. Ultimately, taking the recommended serving size of two capsules might lead to a healthy brain, energy levels, heart and detoxification, and revamped responses to inflammation.
Resveratrol Rapid +
- Company: Nuzena
- Starting Price: $35
Nuzena’s take on Resveratrol entails supporting blood pressure levels and insulin sensitivity while increasing antioxidant contents for anti-aging and longevity. They relied solely on 50% Trans-Resveratrol (1200mg) per capsule to attain these results. Why choose Nuzena? From our viewpoint, this company relies heavily on scientific reasoning for its Resveratrol Rapid +, from ingredients to the precision in dosing. Unlike most companies, this one celebrates lab-testing to the point where results on heavy metal, microbiology, and allergen testing have been posted on their official website. Most of all, a free personal health specialist is included in the form of a 3-minute, 13-question survey that helps to determine which of the several Nuzena solutions is most fitting on an individualistic basis.
- Company: Purely Beneficial
- Starting Price: $25.99
Purely Beneficial believes that their Resveratrol 1450 delivers optimal nutritional value essential for heart and vascular health, normal blood pressure levels, endurance training, and anti-aging, among others. By going with this brand, individuals are supposedly getting “the purest form of key ingredients for [their] body.” As a company, Purely Beneficial intends to provide the highest quality solutions made in U.S. facilities inspected by the FDA. They are so confident with Resveratrol 1450 that they’ve protected each with a 100% satisfaction guarantee.
On that note, every two Resveratrol 1450 capsules are said to represent Vitamin C (120mg), Trans-Resveratrol Complex (from Japanese Knotweed) (605mg), 725mg-Polyphenol Complex of Green Tea Leaf Extract, Grape Seed Extract, Acai Fruit Extract, Red Wine Extract, Pomegranate Extract, Blueberry Extract, Noni Fruit Extract, Alfalfa Leaf Extract, and Hawthorn Berry Extract.
- Company: Reserveage Nutrition
- Starting Price: $22.99
Reserveage Nutrition explained that their take on Resveratrol offers 250mg per serving, enough to help fight free radicals and oxidation caused by aging, environmental factors, and lifestyle choices. In addition to this ingredient, the Resveratrol formula combined with others is trusted to facilitate results, and they are derived from the seeds, skin, and vines of grapes.
As a company founded entirely by women against sacrificing authenticity, confidence, and wellbeing, they believe that Reserveage Nutrition is a go-to that showers everyone with the fundamentals of personal health. The team insists that their line “seamlessly blends outer beauty with inner wellness [allowing individuals] to take control of [their] narrative […] as [they] age.” Yet another brand that informs consumers of the need for science, each product is said to have undergone their embedded in-house quality program and robust audit and testing requirements before launch.
For people thinking that the resveratrol content in this formula is low, Reserveage Nutrition also sells 500mg and 1000mg. Regarding the complete ingredient list, each capsule comprises a 600mg-Pro-Longevity Factors Blend of Japanese Knotweed, Organic French Whole Red Wine Grape (skin, seeds, fruit, stem, and vine), and Organic Muscadine Whole Red Grape and Quercetin (100mg).
- Company: Biotox Nutrition
- Starting Price: $89
Revitaa Pro is an all-natural stress reliever that supports weight loss and promotes heart health. In the opinion of the makers, who we believe is the Biotox Nutrition team, high cortisol levels prevent individuals from losing weight and can go as far as destroying balance among existing hormones. Hence, taking Resveratrol is recommended.
The advertisement for this supplement starts by suggesting Revitaa Pro as the “only product in the entire world derived from raw Japanese Knotweed, sourced directly from the Japanese alps.” We would beg to differ, as there are several resveratrol supplements out there. Sure, this ingredient can be in Japan, China, or Korea, but it is a far stretch to avow that only one company’s ever done it. Another amusing claim that the makers have since made is that “Attacking the true cause of your uncontrolled belly fat and lowering stress levels is so simple with Revitaa Pro [It] is more powerful than any diet or exercise program on the planet.”
If this was the case, wouldn’t everyone do it? In searching more on Biotox Nutrition, we arrived nowhere, which is somewhat concerning. Similarly, each serving appears to deliver 250mg of Resveratrol, a quantity too small for the listed prices. All-in-all, there’s a lot of reflecting to do with this one, especially on the occasions where outlandish promises or claims were made.
The Red Wine Diet
- Creator: Art McDermott
- Starting Price: $14.95
Although our goal was to list potential supplements throughout this piece, we stumbled upon a guide that might be of interest. The Red Wine Diet is a complete guide that provides insight into simple, daily food-wine combinations to help individuals achieve weight loss. Created by Art McDermott, CSCS, CISSN, USAW, this system is meant to help lose 15 pounds within 60 days. In it, Art lists food that should and shouldn’t be avoided, exact meal plans that include red wine, and educational material on our bodies.
After some research, we discovered that Art is a certified nutritionist and strength and conditioning specialist who owns a private training center called Matrix Strength & Fitness. To date, he has over 30 years of experience helping people over 45 years of age improve their mental and physical health. Likewise, he participated in over 25 National and World Championships. He serves as an adjunct professor (University of Massachusetts) and is a board member at PureHealth Research. Validating his credentials was swift, which fostered our expectations for The Red Wine Diet.
- Company: Thorne Research
- Starting Price: $48
Another supplement that offers nicotinamide riboside intending to support the body’s natural aging processes and cellular metabolism is ResveraCel by Thorne Research. Once again, increasing nicotinamide riboside content implies NAD+ production, which boosts cellular energy for healthy aging. In addition, this supplement might support optimal mitochondrial number, structure, and function, healthy methylation, metabolism, blood sugar, and insulin sensitivity, and most of all, ResveraCel is likely to shield DNA from oxidative stress.
Regarding Thorne Research, the company claims to believe that “personalized, scientific wellness can extend the duration of one’s health span and create happier and healthier lives.” This principle is primarily what pushed them to develop products that embody everything from “health tests powered by a proprietary, multi-omic Longevity Health Intelligence platform to advanced nutritional formulas.” Overall, each serving (i.e., two capsules) contains Nicotinamide Riboside (415mg), Quercetin Phytosome (250mg), Trans-Resveratrol (150mg), and Betaine Anhydrous (85mg).
- Company: Toniiq
- Starting Price: $46.99
Elixr is a dietary supplement that brings together the impacts of NMN (i.e., nicotinamide mononucleotide) and Resveratrol on NAD+ and proteins called sirtuins, which are linked to aging and longevity. That said, the Toniiq team prides itself in individually testing each batch while partnering with third-party labs to ensure all ingredients are offered at standardized levels for purity and safety.
Moreover, analyses were conducted to guarantee that their products were free from additives, contaminants, and impurities. Not surprisingly, these measures align with their mission of “enabling people to look and feel AMAZING by combining plant-based nutrients with modern science.” As for the exact breakdown of ingredients per serving (i.e., three capsules), they include Beta-Nicotinamide Mononucleotide (500mg), Resveratrol (98% Trans-Resveratrol) (500mg), and Betaine Anhydrous (500mg).
- Company: Toniiq
- Starting Price: $19.99
Another Toniiq supplement that qualified for this guide is their take on Resveratrol. Each Resveratrol serving (i.e., two capsules) comprises 98% pure Trans-Resveratrol derived from Polygonum cuspidatum extract (600mg). Individuals can gather all the details about the certificate of analysis and third-party independent lab results on the official website.
- Company: N/A
- Starting Price: $79
Vivo Tonic is an 11-in-1 blood support formula designed to help maintain blood sugar levels within normal ranges. As per the claims made, this formula includes a proprietary blend of antioxidants, minerals, vitamins, and herbs inspired by Monks based in Kathmandu. Though the exact supplement’s fact has been omitted at the time of writing, the ingredients have been revealed as Banaba, Corosolic Acid, Silymarin, Berberine, Korean Ginseng, Green Tea, Resveratrol, Cayenne Pepper, Zinc, Chromium, and Alpha Lipoic Acid. Other than those described above, we have very little to discuss here, as transparency is one crucial factor that the makers have failed to reach by the standards of our ranking system.
- Company: Zenith Labs
- Starting Price: $49
As made out in its name, the Longevity Activator is formulated to promote healthy aging at a cellular level. In so doing, individuals can forestall improved memory and brain health, maximum joint comfort, and healthy mood and energy levels. Concerning the makers, Zenith Labs comprises a team of health professionals who see wellness as attainable only if whole-body solutions are implemented. Medical Research Director Dr. Ryan Shelton is responsible for Longevity Activator and claims to have addressed aging by finding a balance between science and nature. Besides formulating solutions, Dr. Ryan is a best-selling author and runs a medical practice in Hawaii.
Nonetheless, each Longevity Activator capsule is meant to offer a good source of Green Tea (100mg), Taurine (100mg), Chebulic Myrobalan Fruit (50mg), Astragalus Root (50mg), Berberine (25mg), Purslane (25mg), Desert Broomrape (25mg), Cordyceps (25mg), Ashwagandha (25mg), Asian Ginseng (25mg), Turmeric (25mg), Resveratrol from Japanese Knotweed (25mg), Pterostilbene (25mg), Fisetin (25mg), L-Carnosine and a 25mg-Absorption Support Blend.
The last product is Vitacell+, and will have a new update for the twenth-inclusion of the product once fully reviewed.
How We Ranked the Best Resveratrol Supplements
Our summary points to one thing: every brand sees the impact of Resveratrol differently. Hence, deciphering them within a category is no small feat unless, of course, a guiding framework is established. In our case, it was a customizable ranking system that permitted us to arrive at the final 20. There are many bad apples even within our top picks, but such errors are typical. Be that as it may, here’s what we prioritized when seeking resveratrol solutions:
Company & Transparency
Does it suffice to have a product in front of you without any other traces of information? The obvious answer to this is no, and even then, people fall for traps found practically everywhere online. When a company fails to stand by its products, it makes us wonder how legitimate they genuinely are. The same applies when information is absent, i.e., supplement’s facts, processes, money-back guarantees, claims made, etc. Speaking of voids, when a brand does not meet transparency at necessary levels, everything should be questioned until answers are given.
Source & Percentage of Resveratrol
At present, the best sources of Resveratrol come from red wine, grapes (and some berries), Japanese knotweed, and peanuts. As we rummaged for resveratrol supplements, we wanted to ensure that companies explicitly stated the source and percentage found per serving. This is a fundamental piece of information that most companies provide, so the lack thereof should be heavily frowned upon.
At large, dietary supplements do not always stop at offering one ingredient. If several elements are involved alongside Resveratrol, we have to ensure that common properties exist. Based on one summary, resveratrol “exerts anticarcinogenic, antiviral, neuroprotective, anti-inflammatory and antioxidant properties.” Ultimately, any ingredient that fails to meet at least one of these properties should be scrutinized some more .
Sometimes reading over the advertised benefits is enough to identify a genuine brand from a sheer scam. Therefore, claims involving short-term recovery or transformation with little change to one’s lifestyle are nearly impossible. In the context of resveratrol ingestion, anything suggesting youthfulness like the good old days within weeks should be examined some more. If a claim comes with no backing, then there’s no point in investing time.
When a company does not meet the mark for credibility, consumer confidence will shrink accordingly. The same goes for any claims made surrounding a supplement. For instance, if a company introduces a solution as being “doctor-formulated” or “physician-formulated,” individuals need to verify their titles and certifications. Having no luck in the search implies a high risk of falsified credentials.
The irony in uniqueness as a factor is that it encompasses several definitions. For us, it was any features that a company took pride in and led them to mark their presence within resveratrol-related solutions. Examples include doctor/physician-formulated, third-party lab testing and postulated results, informative guides, patented and proven ingredients, and money-back guarantees.
Value for Money
Value for money is a specific factor that many people get wrong. For starters, just because a supplement costs a truckload, it doesn’t mean that it is of high quality. Matter-of-factly, some of our most significant finds are priced much lower. A solution is valuable if it meets several of the factors described above while satisfying the crucial ones. Consequently, do the former two matter if a solution has a money-back guarantee and a supplement’s fact yet neglects to list a company name? This is just some food for thought as to how one should navigate through the ranking system.
The Science Behind Resveratrol: To What Extent Is It Effective?
Some of the claims made regarding the effect of Resveratrol were strong, mainly when the alleviated areas include cardiovascular function, diabetes, inflammation, immunity boost, and natural aging, among others that we’ve seen so far. To what extent do these outcomes hold? Are these based solely on natural medicine, or does science truly back them? This is what the next section is devoted to. Here’s an overview of the scientific perspective of Resveratrol.
A 2017 study that looked at the effects of Resveratrol on prosurvival and stressed signaling pathways on 1) oxidative stress, 2) left ventricular function, 3) hypertrophy and fibrosis, and 4) isoproterenol-induced postinfarction heart model arrived at the conclusion that the antioxidant could improve left ventricle function, and decrease interstitial fibrosis, cardiac hypertrophy and level of plasma BNP induced by isoproterenol. Based on the latter, the researchers trust that Resveratrol may benefit heart failure patients through the studied pathways .
Next, we have a 2017 systematic review and meta-analysis that assessed the effects of Resveratrol on glycemic control and insulin sensitivity in patients with type 2 diabetes mellitus. Consequently, evidence for a significant improvement in fasting plasma glucose and insulin levels was reported. Its ingestion supposedly reduced insulin resistance, systolic blood pressure, and diastolic blood pressure among these patients. Such results were deemed possible for a dose of over 100mg/d. Nevertheless, the researchers were convinced by the evidence and noted that “the supplementation of resveratrol may benefit management of T2DM .”
Following suit comes a 2018 randomized, place-controlled, double-blind clinical trial that looked to determine whether resveratrol supplementation affects oxidative stress markers in patients with T2D. Forty-eight patients were either administered 800mg/day or a placebo for two months. By the end, a significant reduction in plasma protein carbonyl content and PBMCs dioxide and an increase in plasma total antioxidant capacity and thiol range was reported in the control group. While the researchers did find evidence for an antioxidant effect in the blood, no improvements were established regarding metabolic parameters, weight, BMI, and blood pressure levels .
Regarding the comparative effect of resveratrol and caloric restriction on longevity-associated gene silencing information regulator (SIRT1) in a 2017 study, significant evidence was established yet again. Precisely, the researchers unearthed that both factors displayed similar anti-aging effects because the duo prevented dihydrochloride-induced senescence and apoptosis. In simpler terms, the pair positively impacted up-regulating TE activity, decreasing oxidative stress, and regulating the SIRT1 pathway .
Diverting from the ingestion of Resveratrol, one 2020 review looked at another prevailing ingredient across some of our supplements. Specifically, the science behind nicotinamide mononucleotide (NMN), its stability, and usefulness were fascinating. In this piece, it was mentioned that when “taken orally, NMN is rapidly absorbed and converted to NAD+,” adding that the increase led to “suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain and more.”
Interestingly, the author referenced Shin-ichiro Imai, who insists that “NMN may improve adult human metabolism, rendering it more like that of someone ten or twenty years younger,” adding that studies are underway to confirm this. Another renowned researcher on this topic, David Sinclair from Harvard University, is also conducting human trials. That said, David allegedly takes NMN and claims to have witnessed an improvement in lipid profile and feels more energetic at 60 years of age. Of course, we can’t take one person’s word for its effects, but NMN’s effectiveness has been assessed through several mice models, all of which have been a great success .
Next, we have a piece that looked at the effects of Resveratrol (i.e., derived from red grapes and red wine) and pterostilbene (i.e., derived from blueberries and grapes) on human health. For those of you wondering why the two are often found together in supplements, one review highlighted that the duo shares pharmacological properties including “antioxidants, neuroprotective, anti-cancer, cardioprotective, analgesic, anti-atherosclerosis, anti-aging, anti-diabetic, anti-inflammatory, and anti-obesity activities.” Existing studies were able to confirm that they can cross the blood-brain barrier and influence brain activity. What surprised us most is that though the duo carries properties in common, pterostilbene has the “stronger pharmacological properties “ of the two .
Another popular pairing is quercetin and Resveratrol, which we’ve noticed across many of the top resveratrol supplements for this year. In search of the duo, we discovered a 2015 study that aimed to determine their anti-inflammatory and antioxidant effects on human conjunctival and corneal epithelial cell lines. By the end, the researchers confirmed that the duo does house the exciting impact on the cell described above lines, adding that “both polyphenols may have therapeutic potential in the treatment of inflammatory ocular surface diseases .”
Ultimately, our preliminary research suggests that there is a lot of potential in ingesting Resveratrol and that the claims made by supplement providers have scientific backing. Though we would have loved to consider other possible combined effects just like we did Resveratrol and pterostilbene and Resveratrol and quercetin, that would result in a book, not so much a guide. Hence, we encourage everyone to use our research as a basis to dive deeper into combined effects. We stress this because supporting ingredients are there for some purpose and should always be thoroughly investigated to ensure set goals, safety, and efficacy are reached.
Frequently Asked Questions About Resveratrol
Q: What is resveratrol?
A: Resveratrol is a type of polyphenolic compound found in certain fruits that acts as an antioxidant, and therefore is trusted to tend to different areas of health.
Q: How do resveratrol supplements work?
A: According to one source, resveratrol supplements could tend to heart disease, cancer, Alzheimer’s, diabetes, and aging, among others. However, they are very conservative in their support, seeing that more is allegedly needed to affirm health benefits .
Q: How does Resveratrol behave as an antioxidant in the body?
A: One source explained that Resveratrol’s antioxidant activity is dependent on its nuclear structure. However, at large, it is deemed effective against hydroxyl and hydroperoxyl radicals. Additionally, it has been exhibited to “protect cells from hydrogen peroxide-induced oxidative stress, while promoting cell survival and protection against UV-irradiation-induced cell death.” Finally, it could minimize or prevent lipid oxidation in pharmaceutical products and maintain nutritional qualities .
Q: What is the difference between Resveratrol and trans-resveratrol?
A: Resveratrol exists as two isomers, i.e., cis- and trans-resveratrol. The latter is desired because it is “more biologically active” than its original form. Hence, trans-resveratrol is likely to affect our bodies more than resveratrol .
Q: What is the difference between 50%, 98%, and 99% trans-resveratrol?
A: The percentages associated with the trans-resveratrol found per serving depict its pureness. Hence, the purest and most costly of the three is 99%, followed by 98% and 50%, respectively.
Q: Is there a relationship between Resveratrol and NAD+?
A: NAD+ is essential for creating energy within our bodily cells while maintaining the integrity of our DNA and building defensive shields against pathogens. Unfortunately, this component is depleted as we age, and one way to activate its presence is by ingesting Resveratrol. One source highlighted that Resveratrol has an indirect effect. Namely, it increases sirtuins proteins, which in turn boosts NAD+ function as required .
Q: Why is NMN so important?
A: While Resveratrol is needed to reactive NAD+, NMN is allegedly necessary to keep sirtuins proteins equipped so that NAD+ function is consistently boosted to heightened levels. This is the main reason why the duo is often seen together in a supplement.
Q: What are the most common sources of Resveratrol?
A: Resveratrol can be extracted from grapes, wine, peanuts, cacao, blueberries, bilberries, cranberries, Japanese knotweed, and 70 other plant species . Among these, the commonly discussed or studied sources are grapes and Japanese knotweed.
Q: What is Japanese knotweed?
A: Also referred to as Reynoutria japonica, Fallopia japonica, and Polygonum cuspidatum, Japanese knotweed is herbaceous, a semi-woody perennial plant found in the knotweed and buckwheat families. Japan isn’t the only place to get this ingredient, as it can be sourced from China and Korea .
Q: What are the best resveratrol supplements to take today?
A: Why look elsewhere? The top resveratrol supplements of 2021 can be reviewed by skimming through this detailed guide!
Q: What properties does Resveratrol possess?
A: As mentioned earlier in our guide, Resveratrol has “antioxidants, neuroprotective, anti-cancer, cardioprotective, analgesic, anti-atherosclerosis, anti-aging, anti-diabetic, anti-inflammatory, and anti-obesity properties .”
Q: What is the recommended dose for Resveratrol?
A: On average, a dose of 250mg and 1000mg is often recommended daily by mouth for up to three months. That said, doses of 1500mg orally are also deemed possibly safe, but to ensure safety, a health practitioner’s opinion should always be sought .
Q: What is the best time of day to take Resveratrol?
A: For maximum sirtuins protein activation, taking each serving in the morning or evening is generally advised. However, studies rarely consider time as a confounding effect. In this case, it might be best to see whether the suggestion described above aligns with the manufacturer’s advice .
Q: Is Resveratrol safe during pregnancy?
A: Resveratrol is likely safe during pregnancy when taken through food sources; however, the ingestion of wine is not recommended. As for supplements, this is a discussion to have with a health practitioner .
Q: Is it safe to take Resveratrol daily?
A: Yes, daily consumption is deemed safe as long as the appropriate dosing is practiced.
Q: Are there any side effects to taking Resveratrol?
A: Doses of over 2500mg are likely to result in nausea, vomiting, diarrhea, and liver dysfunction in patients with non-alcoholic fatty liver disease. Consumers must remain in the safe recommended doses rather than going for highly high ones .
Q: Are there any concerns regarding medication interaction with Resveratrol?
Q: Resveratrol might slow blood clotting; therefore, the addition of certain medications can give rise to bruising and bleeding. Examples of medicines in this regard include (but are not limited to) Plavix, Voltaren, Advil, Anaprox, Fragmin, Lovenox, and Coumadin .
The Top 20 Resveratrol Supplements in 2021 Final Verdict
All-in-all, there’s mounting interest in the effects of Resveratrol on the human body. At the same time, a large portion of scientific evidence is based on animal models, a closely related number of studies involving human participants. This, of course, depends on the area of health of interest, but in general, Resveratrol has backing – whether it be through preliminary studies or more advanced ones. This goes to show that many of our top picks could serve as extra support to alleviate cardiovascular, aging, diabetes possibly, and inflammation- and immune-related conditions.
On that note, by no means are we proposing Resveratrol as a cure for the existing disease. Instead, we firmly believe that its ingestion may help to drive results alongside conventional treatments. Speaking of traditional therapies, individuals must always discuss the potential interactions of taking Resveratrol with other medications, as it could happen. The whole point for supplements is to limit risks; hence, research should be emphasized before investing entirely in a solution. A great starting point could be creating a ranking system or customizing the one our team developed. Ours is broader, seeing that our members each had different factors in mind, but it is okay for the final system to vary from individual to individual.
Until we provide yet another update on top-performing resveratrol supplements, we hope that this guide delivered the essentials of picking products, how to analyze them, why the scientific perspective matters, and together facilitating one’s final decision. We learned that many popularly in-demand products aren’t really what they are made out to be. And thus, additionally showcasing the significance of researching ingredients and claims made through advertisements!
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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.
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